Activation of Serotonin 5-HT<sub>7</sub> Receptors Modulates Hippocampal Synaptic Plasticity by Stimulation of Adenylate Cyclases and Rescues Learning and Behavior in a Mouse Model of Fragile X Syndrome.

Front Mol Neurosci · 2018 · PMC6176069 · PMID 30333723

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When the adenylate cyclase inhibitor SQ 22536 (10 μM) was included in the intracellular pipette solution (Figure 1A ), the amount of mGluR-LTD in WT slices showed a trend towards an enhancement compared to control conditions, although not statistically significant (EPSC % amplitude measured 45 min after LTD induction: 79.5 ± 10, vs. 56 ± 9 comparing control vs.

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