MicroRNA-146a is induced by inflammatory stimuli in airway epithelial cells and augments the anti-inflammatory effects of glucocorticoids.

TNF- α +dex+miR-146a (p = 0.080) did not reach statistical significance ( Fig 3C ). miR-146a enhances the efficacy of dexamethasone, but does not alter potency To further characterize the anti-inflammatory effects of miR-146a, we performed a dose response experiment where cells were transfected with miR-146a or negative control, stimulated with TNF-α, and dex was added at increasing concentrations.

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