ALS-specific cognitive and behavior changes associated with advancing disease stage in ALS.

Jonckheere-Terpstra tests were used on raw ECAS scores specifying a decreasing trend for cognition and an increasing trend for behavior with p values approximated under the central limit theorem for 10,000 permutations.

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While rates of impairment for ALS-nonspecific functions differed between stages 3 and 4, this did not reach statistical significance.

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