Furthermore, donepezil showed a trend towards increased theta phase-gamma amplitude coupling in the hippocampus during stimulation both in WT and TgF344-AD rats; however, coupling strength significantly increased only in adult TgF344-AD rats.
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Neurophysiological signals as predictive translational biomarkers for Alzheimer's disease treatment: effects of donepezil on neuronal network oscillations in TgF344-AD rats.
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