Peanut-specific T cell responses in patients with different clinical reactivity.

Moreover, an analysis of peanut-extract specific IgE titers (listed in Table 1 ) and T cell cytokine production revealed a significant correlation for IL-5 (p<0.0001), IL-17 (p<0.0001) and IL-10 (p = 0.03) production in response to the P19 pool, whereas correlation between sIgE and extract-specific T cell responses only reach borderline significance for IL-5 (p = 0.045) and IL-17 (p = 0.043) ( Table 2 ).

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In contrast, tetramer positive cells in non-symptomatic donors showed a trend for increased level of Integrin β7, a gut-homing factor that plays a role in the regulation of gut-residential regulatory T cells [ 20 ] and immune-regulation of innate responses [ 21 ].

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