Functional recovery after dantrolene-supplementation of cold stored hearts using an ex vivo isolated working rat heart model.

PLoS One · 2018 · PMC6185861 · PMID 30312353

Europe PMC DOI

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0.0890

closest p · 1.8× alpha

0.0890

boldest claim

The sentences

did not reach statistical significancep = 0.089so close (0.05 < p ≤ 0.1)

Histological analysis showed that dantrolene did not alter the number of contraction bands evident after reperfusion of cold-stored hearts except when stored in 40 μM dantrolene which caused a 30% reduction in contraction bands ( Fig 3D and 3E ) but this did not reach statistical significance (ANOVA, p = 0.089).

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a slight trendno p-value reported

Despite a slight trend towards increased CO after 30 minute reperfusion, the observed recovery in 3 month old hearts was not observed in 12 month old hearts ( Fig 5 ).

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