Safety assessment of concurrent statin treatment and evaluation of drug interactions in China.

SAGE Open Med · 2018 · PMC6187411 · PMID 30345053

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quite significantno p-value reported

However, statins share the common metabolic pathways with a number of drugs; therefore, potential DDIs for statins are quite significant. 2 CYP3A4 enzymes are responsible for the metabolism of atorvastatin, simvastatin, and lovastatin, which differ from fluvastatin and pitavastatin mainly metabolized by CYP2C9 (75%), CYP2C8 (5%), and CYP3A4 (20%) via liver and intestinal metabolism.

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