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Mice lacking RAP1 show early onset and higher rates of DEN-induced hepatocellular carcinomas in female mice.

PLoS One · 2018 · PMC6187989 · PMID 30307978

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Indeed, RAP1-deficient females showed significantly larger liver lesions compared to wild-type females ( Fig 1F ), while the differences between RAP1-deficient and wild-type males did not reach statistical significance ( Fig 1G ).

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