CD95/Fas ligand mRNA is toxic to cells.

While there are many sequence differences in the RNA, the predicted 6mer seed toxicity in a number of areas are similar in both constructs (data not shown) and when displaying the toxicity of all sRNAs in a density plot (new Figure 1—figure supplement 3D) the difference between the two constructs did not reach statistical significance confirming that the SIL mutant could still give rise to multiple toxic sRNAs.

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