Mobile elements contribute to the uniqueness of human genome with 15,000 human-specific insertions and 14 Mbp sequence increase.

Among the ME types as targets, the HS-ME density follows a decreasing trend from high to low among LINEs (7.3), DNA transposons (5.0), LTRs (4.0), and SINEs (1.8), seemly correlating with their overall age in the genome from old to new.

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For all MEs as the sources of insertions in MEs, there seems to be an increasing trend from LINEs (17.8%), DNA transposons (22.2%), LTRs (28.2%), SINEs (31.2%), and SVAs (36.5%) with the ratio of SVAs being more than doubled of that for LINEs ( Supplementary Table S6a ).

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In comparison, the ratios of HS-MEs in MEs are more or less similar and lack a clear trend among the ME types ranging from ∼35% for both L1 and LTR to ∼46% for Alu and ∼41% for SVA ( Supplementary Table S6b ).

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