Dopamine-dependent prefrontal reactivations explain long-term benefit of fear extinction.

Indeed, postextinction l -DOPA administration significantly increased the number of potential CS+ offset-related vmPFC pattern reactivations (time × group: F 3,114 = 3.51, P = 0.02, partial η 2 = 0.09; n = 40), particularly 45 min after extinction and there was still a near-significant trend 90 min after extinction (post hoc two-sample t test; pre: P = 0.39; post: 10 min: P = 0.09; 45 min: T 38 = −3.05, P = 0.004, Cohen’s d = 0.97; 90 min: T 38 = −1.95, P = 0.06, Cohen’s d = 0.62; n = 40; Fig. 2e ).

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