Co-delivery of a CD4 T cell helper epitope via covalent liposome attachment with a surface-arrayed B cell target antigen fosters higher affinity antibody responses.

While a slightly higher MPER-specific antibody titer was induced by sLACK formulated liposome vaccines compared to pLACK, a clear trend favoring relatively higher affinity serum antibodies specific to both MPER and LACK ( Fig. 5 C) was evident with surface associated pLACK immunizations.

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