In contrast, cleaved caspase-3 levels appeared to be elevated after receiving oral doxycycline; however, this did not reach statistical significance, except in the case of low histological grade (See Table S4 ).
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Doxycycline, an Inhibitor of Mitochondrial Biogenesis, Effectively Reduces Cancer Stem Cells (CSCs) in Early Breast Cancer Patients: A Clinical Pilot Study.
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