Two other miRNAs, miR-34a and miR-106b, were borderline significant in the univariable analysis (Table 4 ), but were not retained in the multivariable model selection procedure (Table 3 ).
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Age-related microRNAs in older breast cancer patients: biomarker potential and evolution during adjuvant chemotherapy.
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With regard to the correlations between the aging miRNA panel and other biomarkers of aging, 6 of the selected miRNAs (though 3 of them failed to reach statistical significance in the multivariable analysis), correlated with circulating levels of IL-6, a well-known aging biomarker [ 24 ] that we previously also found to be predictive of frailty [ 5 ].