Coronary artery disease genes SMAD3 and TCF21 promote opposing interactive genetic programs that regulate smooth muscle cell differentiation and disease risk.

PLoS Genet · 2018 · PMC6198989 · PMID 30307970

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nominally significantno p-value reported

By employing this approach, the regression coefficient was 0.45, with a nominally significant p -value of 0.08, suggesting that SMAD3 expression increases with a greater number of cis-acting risk alleles as per an additive model ( Fig 5B ).

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highly significantno p-value reported

This subcategory was felt to be particularly pertinent to the molecular and cellular basis of CAD, based on the highly significant enrichment for such terms in the IPA analysis of the CAD GWAS meta-analysis genes [ 7 ], and the close match to terms in this category found here with SMAD3 knockdown transcriptomic analysis.

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