Can We Improve Stavudine's Safety Profile in Children? Pharmacokinetics of Intracellular Stavudine Triphosphate with Reduced Dosing.

Antimicrob Agents Chemother · 2018 · PMC6201115 · PMID 30104267

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possibly significantno p-value reported

Then, the plots of individual random effects (empirical Bayes estimates) ( 29 ) versus covariates were used to screen possibly significant trends in the data.

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did not reach statistical significanceno p-value reported

There was a trend toward slightly lower bioavailability for the children, but this did not reach statistical significance and did not provide convincing improvements to the diagnostic plots and VPCs.

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