Delivery of shRNA via lentivirus in human pseudoislets provides a model to test dynamic regulation of insulin secretion and gene function in human islets.

Physiol Rep · 2018 · PMC6204361 · PMID 30370689

Europe PMC DOI

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0.2000

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showed a trendP = 0.20not close (p > 0.1)

Although pseudoislets showed a trend of reduction in first/second phase SI (mean ± SD = 1.73 ± 0.6) compared with fresh islets ( P = 0.20), the ratio was higher compared with cultured‐intact islets ( P < 0.05, Fig. 2 C).

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