An RORγt Oral Inhibitor Modulates IL-17 Responses in Peripheral Blood and Intestinal Mucosa of Crohn's Disease Patients.

Front Immunol · 2018 · PMC6204372 · PMID 30405600

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did not reach statistical significanceno p-value reported

Other genes that are significantly regulated in CD mucosa compared to non-IBD controls (data not show) such as IL23R, CSF2, CXCL1, CXCL8, IFNG, S100A8, IL6, IL10 , and DEFA5 were also significantly changed by BI119 in ileal CD, whereas the effect on colonic biopsies did not reach statistical significance in most cases.

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