Insights into the evaluation and management of dyspepsia: recent developments and new guidelines.

Instead, there were a handful of trials comparing prokinetics with PPIs, with the meta-analysis performed to inform the guideline demonstrating a trend in favour of PPIs, although this did not reach statistical significance. 7 Conversely, in the treatment of FD, a previous meta-analysis of RCTs showed prokinetics to be more effective than placebo, 74 an effect which was confirmed in an updated meta-analysis for the ACG/CAG guidelines. 7 This showed a statistically significant, albeit modest, effect of prokinetic therapy in reducing global FD symptoms with a RR of remaining dyspeptic of 0.92 (95% CI 0.88–0.97).

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