The odds ratio for the association between AEDs and suicidal behavior or ideation was 1.8 (95% CI, 1.24–2.66) and 1.45 (95% CI, 0.93–2.3) for ideation alone, which did not reach statistical significance.[ 31 ] The validity of this meta-analysis was questioned after careful review of the data based on several methodological problems, including the source of outcome data on suicidality, statistical methodologies used, heterogeneity of the trials, and the difference in mechanism of action of the 11 AEDs evaluated.[ 11 ] The suicide attempt rates before and after gabapentin was prescribed were investigated in a cohort of 131,178 patients.
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