As shown in figure 2 , h-tau mice receiving the diet had a statistically significant increase in levels of homocysteine (Hcy), and S-adenosyl-homocysteine (SAH), and a reduction in the levels of S-adenosyl-methionine (SAM) which did not reach statistical significance.
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Elevated levels of brain homocysteine directly modulate the pathological phenotype of a mouse model of tauopathy.
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