IFNα Impairs Autophagic Degradation of mtDNA Promoting Autoreactivity of SLE Monocytes in a STING-Dependent Fashion.

Interestingly, STING knockdown substantially reduced IFNα-mediated IL6 secretion while TNFα secretion was also reduced but did not reach statistical significance (p = 0.0626) ( Figure 6 C), suggesting that STING sensing can control type I interferon-mediated response to immunogenic nucleic acid presence in the cytoplasm.

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