A brain-penetrant triazolopyrimidine enhances microtubule-stability, reduces axonal dysfunction and decreases tau pathology in a mouse tauopathy model.

Mol Neurodegener · 2018 · PMC6223064 · PMID 30404654

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did not reach statistical significanceno p-value reported

None of the treatment groups showed meaningful body weight loss and PS19 mice receiving 51657 showed somewhat less body weight loss than did the vehicle-treated PS19 mice, although this difference did not reach statistical significance (Additional file 1 : Figure S3).

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