Association study between <i>COMT</i>, <i>DRD2</i>, and <i>DRD3</i> gene variants and antipsychotic treatment response in Mexican patients with schizophrenia.

The analysis of the Ser9Gly of DRD3 gene showed a trend for significance, showing a high frequency of the Ser/Gly genotype and the Gly allele in the ultra-resistance group compared with the responder group; one current study using next-generation sequencing reported an association between Gly allele and a poorer response. 37 In contrast, Shaik et al, 45 Scharfetter et al, 19 and one recent meta-analysis (Gressier et al 46 ) found an association between ultra-resistant patients and the Ser allele.

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