Reductions in mRNA level of mitochondrial proteins are often fairly small, but are clearly significant as recent proteomic studies in worms and mammals have discovered matching reductions in the ETC, ATP synthase, the tricarboxylic acid cycle and mitochondrial ribosomal proteins (Gomez-Serrano et al. 2017 ; Liang et al. 2014 ; Nishtala et al. 2013 ; Ori et al. 2015 ; Stauch et al. 2015 ; Walther et al. 2015 ; Xu et al. 2016 ).
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