2b ) and, consistently, a highly significant negative deviation of most parameters at the distal site, (particularly mean, max and median speed) whereas the proximal signature parts remained mostly unaltered ( Fig. 2c , pink and black signatures), consistent with local disruption of organelle motility and tight adherence of the MFC ( Fig. 2a ).
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High content organelle trafficking enables disease state profiling as powerful tool for disease modelling.
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Following common statistical standards, we regarded Z-score values of 1 only as theoretical border line significance and considered a more stringent minimum of 5 as clearly significant deviation from Ctrl conditions ( Fig. 2c , marked Z-score range from -5 to 5).