Stress alters social behavior and sensitivity to pharmacological activation of kappa opioid receptors in an age-specific manner in Sprague Dawley rats.

3 F) the suppressing effects of the lowest dose did not reach statistical significance whereas a U-62066-related decrease in play fighting was seen at all doses in stressed juveniles. 3.4 Locomotor activity ( Table 1 ) The analysis of general locomotor activity under social circumstances indexed via total number of crossovers between compartments revealed significant main effects of age, F (2, 300) = 25.39, p < 0.0001 and drug dose, F (4, 300) = 143.27, p < 0.0001 but no main effect or interactions involving sex and/or stress condition.

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