Connexin 30 Deficiency Attenuates Chronic but Not Acute Phases of Experimental Autoimmune Encephalomyelitis Through Induction of Neuroprotective Microglia.

Colocalization of Iba-1 and arginase-1 was more frequently observed in the optic nerve and cerebellum of Cx30 KO mice compared with WT littermate mice ( p = 0.012, and p = 0.0041, respectively; determined by higher mean Pearson's coefficient values; Figures 6A–D ), although differences in colocalization levels between WT and Cx30 KO mice did not reach statistical significance in the spinal cord, possibly because of the infiltration of peripheral blood-borne macrophages (Figures 6E,F ).

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