Astrocyte HIF-2α supports learning in a passive avoidance paradigm under hypoxic stress.

Assessment of glucose and lactate transporters (Glut-1 and MCT-4), PDK-1 (inhibitor of pyruvate dehydrogenase), and LDHA showed a trend in which they appeared to be regulated by HIF-1α and not HIF-2α ( Figure 9B and C ), sug gesting that insufficient metabolic adaptation in the HIF-2α null animals may not be the cause of the observed learning and LTP impairment.

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