Isogenic Pairs of hiPSC-CMs with Hypertrophic Cardiomyopathy/LVNC-Associated ACTC1 E99K Mutation Unveil Differential Functional Deficits.

In contrast, highly significant (p < 0.001) differences were seen in all three BNP populations for E99K1 versus E99K1-Corr, wherein E99K1 was 6.92- and 2.97-fold higher for BNP-high and -low cells, respectively, but 6.12-fold lower for BNP-negative cells.

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Analysis of sarcomere assembly showed a trend, albeit non-significant, toward increased disarray in E99K-expressing hiPSC-CMs ( Figure S7 ).

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