Colorectal cancer liver metastatic growth depends on PAD4-driven citrullination of the extracellular matrix.

Nat Commun · 2018 · PMC6235861 · PMID 30429478

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PAD4 levels in lysates of human liver metastases showed a trend to be increased compared to the adjacent liver based on ELISA measurements and were significantly increased based on immunoblotting (Fig. 3a, b , Supplementary Fig. 6A, B).

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