Higher diuretic dosing within the first 72 h is predictive of longer length of stay in patients with acute heart failure.

Anatol J Cardiol · 2018 · PMC6237957 · PMID 30088485

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an increasing trendno p-value reported

As a result, the mean diuretic dose in the first 72 h showed an increasing trend during the study period ( Fig. 1 ).

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showed a trendno p-value reported

The Diuretic Optimization Strategies Evaluation (DOSE) trial showed a trend toward greater improvement in patients’ symptom when using a high-dose diuretic strategy in the first 72 h of hospitalization than when using a low-dose strategy; however, a significantly higher incidence of creatinine level increases was also observed in the high-dose group ( 2 ).

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