Disruption of stromal hedgehog signaling initiates RNF5-mediated proteasomal degradation of PTEN and accelerates pancreatic tumor growth.

Although multivariate analysis did not reach statistical significance in the entire cohort, univariate subgroup analyses showed that the association between PTEN score and overall survival was statistically significant for the group of patients older than 60 y, but not for those 60 or less (Table S1B and C; P = 0.003 and 0.609, respectively).

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