Crispr/Cas Mediated Deletion of PTPN22 in Jurkat T Cells Enhances TCR Signaling and Production of IL-2.

Front Immunol · 2018 · PMC6240618 · PMID 30483260

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did not reach statistical significanceno p-value reported

However, there was a very slight but consistent increase in the average phosphorylation of residues in stimulated PTPN22 KO cells, although this did not reach statistical significance.

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a slight trendno p-value reported

Once again there was a slight trend for PTPN22 KO clones to cluster toward the higher range of peak calcium flux value, which likely accounts for the slightly steeper slope as they returned to baseline, but overall the variance was such that this difference was not statistically significant.

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