Iron-enriched diet contributes to early onset of osteoporotic phenotype in a mouse model of hereditary hemochromatosis.

In contrast, both parameters appeared to be increased in the KO mice under an iron rich diet, despite being at the limit of significance, consistent once again with the micro-CT data Evaluation of the correlation between N.Oc/B.Ar relatively to Tb.N, Tb.Sp and SMI showed a statistical significant linear correlation between N.Oc/B.Ar and Tb.N (p<0.0014), Tb.Sp (p<0.0150) and SMI (p<0.0280), with negative correlation for Tb.N and positive correlation to Tb.Sp and SMI, ( Fig 6B ).

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There appeared to be a consistent increase in both groups under the iron enriched diet, although only clearly significant for the expression of Il6 in the WT and for the Tnf in the Hfe-KO mice ( Fig 2C ) suggesting that the dietary iron overload promoted inflammation.

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