Multi-OMICS analyses of frailty and chronic widespread musculoskeletal pain suggest involvement of shared neurological pathways.

Epigenome-wide association study of Frailty Index Testing 723,029 lsBINs in 50 FI discordant MZ twin pairs (Gr1) implementing paired t tests revealed overall N D = 27,485 bins that showed nominally significant associations ( P < 0.05), and of these, the top 20 association signals were ranged P = 7.01 −5 to 2.17 −6 .

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However, of them, 103 metabolites represented unknown biochemical compounds and were excluded from the following analyses, despite highly significant correlations in some instances.

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