Reduced Efficacy of d-Amphetamine and 3,4-Methylenedioxymethamphetamine in Inducing Hyperactivity in Mice Lacking the Postsynaptic Scaffolding Protein SHANK1.

Although basal DA levels clearly tended to be lower in Shank1 -/- mice, apparent genotype differences in DA levels did not reach statistical significance ( F 2,38 = 3.192, p = 0.052; Figure 7C ), while the concentration of the DA metabolite DOPAC differed between genotypes ( F 2,40 = 3.879, p = 0.029; Figure 7D ).

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