Oncogenic KRAS supports pancreatic cancer through regulation of nucleotide synthesis.

Nat Commun · 2018 · PMC6251888 · PMID 30470748

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The decrease in nucleotide biosynthesis was confirmed by N15-Glutamine tracing studies, which showed a trend towards lower incorporation in sensitive cell lines as compared to resistant for pyrimidines (Supplementary Fig. 4d ) and more significantly purines (Fig. 3d ) upon MEK inhibition.

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