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Influence of age and renal impairment on the steady state pharmacokinetics of filgotinib, a selective JAK1 inhibitor.

Br J Clin Pharmacol · 2018 · PMC6256002 · PMID 30088677

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a clear trendno p-value reported
Although the number of subjects included in each RI group was small ( n = 3–6), the results of the present study showed a clear trend of increased exposure associated with decreased renal function.

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