Barely Significant
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Malignant transformation of canine oral papillomavirus (CPV1)-associated papillomas in dogs: An emerging concern?

Papillomavirus Res · 2018 · PMC6260289 · PMID 30414951

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a strong trendno p-value reported
When reviewing the annual submission rate of all cases microscopically consistent with viral papillomas with transformation toward a malignant phenotype in comparison to our overall submissions, there is a strong trend toward a 2–3 fold increase of the number of such cases between 2006 and 2014.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.