Effect of fish oil omega-3 fatty acids on reduction of depressive symptoms among HIV-seropositive pregnant women: a randomized, double-blind controlled trial.

This “placebo effect” might have influenced the mean change in BDI-II depressive symptom scores of the groups, causing “regression to the mean” value, where the mean change in depressive symptom scores showed a trend towards the treatment effect [ 57 ]. “Regression to the mean” was controlled in this study through the ANCOVA analysis model, which adjusted for any extreme baseline values and variability during analysis.

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