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Severe-combined immunodeficient rats can be used to generate a model of perinatal hypoxic-ischemic brain injury to facilitate studies of engrafted human neural stem cells.

PLoS One · 2018 · PMC6261629 · PMID 30485360

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KO injured animals displayed significant ventriculomegaly in the right hemisphere ( Fig 9B ), while WT injured animals showed a trend toward ventriculomegaly in the right hemisphere ( Fig 9C ).

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