Divergent Innate and Epithelial Functions of the RNA-Binding Protein HuR in Intestinal Inflammation.

Contrary however to the ascribed role of IEC-HuR in intestinal regeneration ( 16 , 18 ), IEC-HuRko mice mounted a stronger crypt hyperplastic counter-response maintained even till day 25, which was associated with a near-significant upregulation in crypt proliferation as assessed via Ki67 immunostainings during the peak of the disease at day 12 (Figures 3A,C,D ).

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This was also revealed when TgATFHuR + mice were tested for sensitivity to systemic effects occurring in LPS-induced endotoxemia where these mice displayed only a mild trend of resistance to lethality (Figure 4C ).

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