Longitudinal Association between <i>n</i>-3 Long-Chain Polyunsaturated Fatty Acid Intake and Depressive Symptoms: A Population-Based Cohort Study in Japan.

Another meta-analysis suggested that only regimens containing over 60% EPA had a highly significant effect in the treatment of depression [ 55 ].

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Marginally significant differences were observed for marital status and history of diabetes. 3.2.

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Moreover, the HR showed a decreasing trend with level of intake of both EPA ( p for trend = 0.009) and DHA ( p for trend = 0.032).

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No significant associations were observed with n -6 PUFA levels, but the n -6: n -3 ratio showed a significant trend of association with the onset of depressive symptoms.

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The findings of these studies were found to be partially significant and not dose-dependent.

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