Deep Multi-OMICs and Multi-Tissue Characterization in a Pre- and Postprandial State in Human Volunteers: The GEMM Family Study Research Design.

The postprandial leptin, insulin levels and gastrointestinal satiety signals involved in neurohormonal regulation of energetic homeostasis (GLP-1, PYY), the fasting inflammatory biomarkers (TNFα, hs-CRP, PAI-1, IL-6), and the biochemistry markers of lipid-lipoprotein metabolism (NEFA, triglycerides, C-HDL), clearly showed a trend to be elevated in our group with higher BMI values, except for postprandial ghrelin lower levels ( Table 1 and Table 2 ).

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