Safety and efficacy of aged garlic extract in dogs: upregulation of the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway and Nrf2-regulated phase II antioxidant enzymes.

There was no statistically significant difference in body weights among the three groups during the experimental period (Additional file 2 ) Hematology There was almost no observable change in the data obtained from complete blood count (CBC) and blood smear examinations, except for a slightly significant change ( p < 0.05) of the reticulocyte count between the group administered AGE at a dose of 45 mg/kg group and the control group a week after the administration (Table 1 ).

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