Mechanistic study of the spiroindolones: a new class of antimalarials.

Molecules · 2012 · PMC6268731 · PMID 22922283

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a clear trendno p-value reported

In all instances trans isomer 3a was the major product, irrespective of the reaction conditions, although there was a clear trend towards higher diastereoselectivity at lower temperatures.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.