Sex differences in the hepatic cholesterol sensing mechanisms in mice.

Expression of Cyp7a1 , the rate-limiting step in BA synthesis, tended to be higher in females than males on HFC diet ( p = 0.09) and females showed a trend of increased Cyp7a1 expression in the cholesterol loaded diet ( Figure 5 A).

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The sex effect was highly significant and plant sterols were higher in females on both types of diet with the exception of sitosterol on the HFnC diet ( Figure 3 ). 2.3.

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