Synthesis of Canthardin Sulfanilamides and Their Acid Anhydride Analogues via a Ring-Opening Reaction of Activated Aziridines and Their Associated Pharmacological Effects.

Molecules · 2016 · PMC6273973 · PMID 26784163

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showed a trendno p-value reported

Yields varied 2%–62% and showed a trend compatible with the expected basicity, and the characters of the bulky quinoxaline and the more-basic carbamide groups influenced compounds 5d (6% yield) and 5e (2% yield).

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