Co-Evolution of Intrinsically Disordered Proteins with Folded Partners Witnessed by Evolutionary Couplings.

Comparing EC IFs and ECs to all IFs, we found no significant differences either for IDPs ( Figure 4 , Supplementary Figure S2 ) or their partners ( Supplementary Figure S3 ), although the enrichment of the EC-carrying interfaces of IDPs in negative residues was nearly significant ( p = 0.0519).

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